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9.6: Exercise 2 - The BLOSUM62 matrix - Biology

9.6: Exercise 2 - The BLOSUM62 matrix - Biology


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  1. Find the BLOSUM scores for the conservative substitutions that you sggested in Exercise 1. Does the BLOSUM data support your hypotheses?
  2. Find the two substitutions with the highest BLOSUM scores. In what ways are the biochemical properties of the substituted amino acid similar or dissimilar to the amino acid that it replaces?

3. What special features do these amino acids have?


The 9-box model is powerful because of its simplicity and effectiveness. From the experience of Predictive Success CEO David Lahey, the model works 95% of the time and only runs into trouble when communication is not transparent. The model is composed of 9 boxes arranged on an x and y axis grid, with performance measured along the x-axis, and potential measured along the y-axis. The most valuable position is the top right box, which is composed of those ranking high in both performance and potential. Conversely, the bottom left box is the place for those ranking low in both categories.

This illustration is a catalyst for constructive dialogue and in turn, will facilitate discussion, teamwork, and development. The idea behind the matrix is that by identifying how each employee fits into the grid, you can better understand where each employee stands and how they should be positioned in future organizational shifts.

For all 9-box models, a leadership competency model must be created. These models are made to highlight the leadership skills and behaviors that contribute to peak performance. When succession planning, a competency-based approach can help organizations decide best fit for their future leaders.


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