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What is a good non-fluorescent DNA dye?

What is a good non-fluorescent DNA dye?


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Can anyone suggest a dye which specifically targets DNA, but is not fluorescent? We plan to mark DNA before observing it with RAMAN-Spectroscopy. Because of the weak signal, even a low emission would disturb the reading.


One option is to use biotin labelling. Most molecular biology supply companies do kits for this, and supply biotinylated nucleotides.


Methylene blue? Certainly not as sensitive or specific as other options but it's cheap and does not fluoresce.